Free Radicals of Biochemical Importance. Attachments 1, 2, 3

摘要

Hypochlorous acid (HOC1) is a cytotoxic agent that arises from the hydrolysis ofchlorine gas upon contact with atmospheric humidity of the moist environment of the lung. It is also formed endogenously in animals as an end product of oxygen metabolism by activated phagocytes, which produce it as a means of defense against foreign cells. Although HOC1 is highly toxic, the mechanisms by which it exerts its toxicity is unclear. The principal investigator has found that adenine nucleotides react vigorously with HOC1 to yield an unstable derivative that has been isolated and found to be associated with a free radical that is capable of forming oligomers. The research of the current period has been directed toward eludicating the structure of this unstable derivative and characterizing the nature of radical that it forms.