Soman in the Respiratory Tract: Work Performance During Soman Intoxication

摘要

A cross ventilated rodent model for the study of the distribution of soman in therespiratory tract was developed. The physiological status of the model was evaluated over a 3 to 4 hour period and found to be acceptable for the purposes of these studies. Other significant accomplishments include the development of tissue solubilization procedures for the compartmental analyses of soman distribution; the adaptation of established cholinesterase assays for microsamples of whole blood and plasma; and the development of refinement of several assays for alveolar macrophage viability and functionality. Keywords: Lab animals; Soman vapor; Alveolar macrophages; Chemical agents; Monoclonal antibodies; Inhalation toxicology.(JS)