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Analysis of a Middle Eastern Soil Sample for Chemical Warfare Agents

机译:化学战剂中东土壤样品分析

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A soil sample originating from a Middle Eastern area of chemical warfare activitywas subjected to chemical and biochemical analysis. Sarin and several related compounds were confirmed in the soil by capillary column GC-MS, however, the binding of these compounds to the soil hindered quantitation. The chemical results were then compared to those obtained by biochemical means in primary cultures of chick embryo forebrain neurons. By comparing the sample's anticholinesterase activity against those of purified standard nerve agents in chick embryo neuron cultures, a reasonable agreement was found between the chemical and biochemical quantitative estimates of sarin content in the soil extract. Furthermore, the in vitro system appears to offer sensitive technique for the estimation of sarin remaining bound to the soil following solvent extraction. Chemical agents. (js)

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