Comparison of Gemfibrozil and Lovastatin Therapy in Patients with High LDL andLow HDL Cholesterol Levels

摘要

Pharmacologic interventions in primary hypercholesteremia are usually consideredafter saturated fat restricted diet has failed to achieve an adequate control. The specific drug selected may be based, among other things, on its cholesterol lowering efficacy, ability to incidence of coronary heart disease (CHD), long term safety record, and cost. In addition, the individual patient lipoprotein profile and the established agents on specific profile components may be considered. Framingham, MRFIT, and epidemiological studies demonstrated that patients with increased low-density lipoprotein (LDL) cholesterol Clinics Trial showed that lowering elevated levels of LDL cholesterol significantly lowered the risk of CHD development. (JS)