Stereospecificity of Antidotes and Their Mechanism of Action in Intoxicationswith Organophosphorus Anticholinesterases

摘要

Our program during the last year has mainly been concerned with studies on: theeffect of diazepam on 1-hyoscyamine binding in the old stock of sick and healthy mice and new stock of healthy mice, the usability of 1-hyoscyamine binding for studies of specific receptor distribution in brain, effect of different combinations of antagonists (1-hyoscyamine, diazepam, H1-6) on acetycholine turnover, and duration of the effect of diazepam on acetylcholine turnover. There is a significant difference between the old and new stock of mice as far as the influence of diazepam on 1-hyoscyamine binding is concerned. In order that optimal parameters can be determined, therefore, the model needs further development in the new stock of mice. Keywords: Acetylcholine, Choline, Diazepam, Hyoscyamine, HI-6, Cholinesterase inhibitors, RA 5. (JS)