Natural History of HTLV III Infection in USAF Personnel: Clinical Evaluation,Laboratory Evaluation, Assessment of In vivo and In vitro Immunologic Status, and Data Storage (Final Report)

摘要

'Natural History of HTLV III Infection in US Air Force Personnel: ClinicalEvaluation, Assessment of In Vivo and In Vitro Immunologic Status, and Data Storage' has been a multildisciplinary, multiyear investigation involving a clinical, laboratory and immunological investigation into the natural history, the study of neuropsychiatric and neurological natural history, and the clinical history of transition from asymptomatic HIV infection to symptomatic disease and frank AIDS. During the period of this project, 989 individuals were entered into the WHMC HIV database. Of these, 645 were Walter Reed stage 1; 122 were Walter Reed stage 2; 47 Walter Reed stage 3; 29 Walter Reed stage 4; 47 Walter Reed stage 5; and 43 Walter Reed stage 6 at initial diagnosis. Fifty-six were of uncertain WR stage. Upon re-evaluation, overall rate of progression to higher Walter Reed stage was approximately 15% per year with a lower number in the Walter Reed stage 1 and 2 and a much higher number in Walter Reed stage 3 through 6 advancing yearly. Keywords: Required immune deficiency syndrome; Disease progression; Active duty military; Neurological disease; Prognostic markers of disease progression; Sensory-neural. (JES)