Covalent Incorporation of 3'-O-(4-Benzoyl)benzoyl-ATP into a P2 Purinoceptor inTransformed Mouse Fibroblasts

摘要

Extracellular ATP has hormone- and neurotransmitter-like effects in a variety ofmammalian tissues. For example, ATP modulates muscle contraction and relaxation, vascular tone, secretion of insulin, prostacyclin, endothelium-derived relaxing factor and amylase, platelet aggregation, immune responses, neurotransmission, plasma membrane permeability properties, and cell growth. Sources of extracellular ATP include neurons, platelets, and adrenal medullary cells which release ATP from storage granules in response to electrical or chemical stimulation. Micromolar levels of extracellular ATP have been reported in the perfusate of exercising skeletal muscle and in response to tissue damage or shock, and nanomolar levels of extracellular ATP have been demonstrated in hypoxic tissues. (JES)