Comparison of Cholinergic Effects of HI-6 and Pralidoxime-2-Chloride (2-PAM) inSoman Poisoning

摘要

The effects of HI-6 and pralidoxime chloride (2-PAM) on soman-induced lethality,time to death and several cholinergic parameters in rats were compared to understand the beneficial action of HI-6. Treatment with atropine sulfate (ATS) of HI-6 alone protected against 1.2 and 2.5 LD of soman respectively, whereas 2-Pam or methylated atropine (AMN) alone afforded no protection. Addition of ATS, but not AMN, to HI-6-treated rats enhanced the protection from 2.5 to 5.5 LD. HI-6 increased the time to death, while 2-PAM had no effect; a combination of HI-6 and ATS provided the most significant increase in time-to-death.