Research Progress Report Submitted to the U.S. Naval Medical R D Command

摘要

The research activities described in this progress report have been supported inpart by a three basic research contract from the U.S. Naval Medical Research and Development Command which begins on May 15, 1990. This progress report summarizes our basic research efforts since November 9, 1990, the date of Cryopharm's last progress report. As described in our November progress report, Cryopharm's 1991 milestones are two-fold: 1) continued basic research to produce overall improvements in both the biophysical and biochemical membrane properties of lyophilized reconstituted red cells with the goal of improving their in vivo survival; and 2) continued clinical safety and circulation studies of lyophilized autologous red cells in normal volunteers, to study the correlation between observed biophysical properties and in vivo cell survival. The basic research section of this report outlines our progress in investigating various ways to reduce oxidative damage to the red blood cells during our lyophilization process.