Modification of Pituitary-Adrenal Axis Responses to Hemorrhage by HandlingTechniques in Conscious Swine

摘要

Increases in plasma ACTH concentration during hemorrhage are closely coupled todecreases in blood pressure, a response that is regulated mainly by baroreceptors sensing a reduction in vascular volume. This relationship of ACTH to a hemorrhage-induced change in blood pressure can be modified by a number of factors, including time of day, prior hemorrhage, anesthesia, hyperthermia due to infection, and pain. In addition, recent work by Carlson et al. demonstrates that ACTH responses to hemorrhage are affected by the training procedures used to train, or condition, pigs to accept physical restraint in a Pavlov sling. Their data show that more intensively trained pigs have lower resting values for plasma ACTH than less intensively trained pigs.