Prophylaxis and Treatment of Newborn Endotoxic Shock with Anti-Lipid A MonoclonalAntibodies

摘要

Gram negative sepsis septic shock continues to cause high mortality in newborns.Newborn endotoxic shock has been reported to have a different pathophysiology than the adult. The immature systems in the newborn are responsible for the different patho-physiology of endotoxic shock. The complex physiology of the newborn causes difficulty of endotoxic shock treatment. Endotoxic shock is induced by lipopolysaccharide, an essential component of the outer membrane in gram-negative organisms. Therefore, immunoglobulins against lipopolysaccharides have been used for the treatment of gram-negative sepsis/septic shock.