Characterization of the Interaction of the Radioprotector 1-Methyl-2(2-(Methylthio)-2-Piperidinovinyl)Quinolinium Iodide with Supercoiled DNA

摘要

Numerous chemicals have been investigated for their radioprotective ability. Themost widely studied class of antiradiation compounds are the aminothiols, initially synthesized by the U.S. Army Medical Research and Development Command at Walter Reed Institute (1). The mechanism at the molecular level by which aminothiols confer protection is not known with certainty, although a number of possibilities have been suggested, including free radical scavenging, hydrogen atom exchange, enhancement of DNA repair, and activation of cellular enzymatic processes. Studies by Zheng et al. and Smoluk et al. have demonstrated the importance of the interaction of molecules of the radioprotective compounds with DNA. Recently Foye and co-workers have introduced a new class of radioprotective