Receptor-Mediated Elimination of Phosphocholine-Specific B Cells in X-LinkedImmune-Deficient Mice

摘要

The combined expression of the M167 anti-phosphocholine (PC) transgenes with thex-linked immunodeficiency gene, xid, results in an almost total failure to develop B cells in the peripheral lymphoid organs of such mice. Although there is no significant difference between the normal transgene positive (TG+) female offspring and the immunodeficient TG+ xid males with respect to the number of B220+ pre-B cells and IgM+B220B cells that develop in their bone marrow, the hemizygous xid males have 85 % fewer B cells in their spleens than the phenotypically normal heterozygous F1 females.