2-Acetylpyridine Thiosemicarbazones. 13. Derivatives with Antifilarial Activity

摘要

Filariasis is the term applied to a group of systemic nematode diseases caused bythe transmission of infective larvae of filariae to men by the bite of certain mosquitos or blackflies. The macrofilariae (adult worms) inhabit the body cavities, tissues, or circulatory system of the host. Restriction of the lymphatic vessels by adult worms can cause dramatic enlargement of the lower extremities, such as that seen in elephantiasis. Among the important members of this family of filarial nematodes that infect man are Wuchereria bancrofti, Brugia malayi, O. volvulus, and Loa loa.