Upstream Promoter Elements of the Herpes Simplex Virus Type 1 Glycoprotein H Gene

摘要

Studies designed to define the DNA sequences involved in regulation andexpression of herpes simplex virus type 1 (HSV-1) late genes have shown that sequences upstream from the TATA element of the glycoprotein C (gC) gene can be deleted without affecting expression. Other studies have shown that a 15-bp sequence containing the gC TATA element is absolutely required for expression and that deletion of sequences containing the start of transcription and the 5' noncoding region of the gC gene eliminate expression from this late promoter. Furthermore, expression from hybrid promoters, consisting of sequences from both the early thymidine kinase gene and late UL42 promoters, indicated the regulatory domains of late promoters are downstream from the TATA element.