Epidemiologic Aspects of Shigellosis and Other Causes of Dysentery in Thailand

摘要

Human erythrocyte muscarinic receptor is further classified as M1 subtype by itsbinding of (3H)pirenzepine (a specific M1 agonist). Conversely, binding of (3H)piperidinyl AF-DX116 (a specific M2 antagonist) is not detected. There are high correlations between the binding efficacies of 25 known or putative cholinergic agents using either human erythrocyte membrane or mouse caudate homogenate. Also the in vitro data corresponds satisfactorily with in vivo data measuring the protective effect of these compounds against organophosphate poisoning. The human erythrocyte membrane is an efficient model for investigating cholinergic agonists and antagonists.