Red Blood Cell Cholinesterase Activity and Plasma Pyridostigmine Concentrationduring Single and Multiple Dose Studies

摘要

Administration of pyridostigmine bromide (PB) has been chosen by the U.S. Army asa pre-treatment for anticipated nerve agent exposure for soldiers deployed in areas with threat of CW exposure. We gave 36 healthy adults 30 mg PB (p.o.) and measured red blood cell cholinesterase (RBC AChE) activity after a single dose (HURC 306, 330, and 378) and during multiple dose PB treatment (HURC 377 and 403). PB was given at 0600 h, 0700 h, or 0800 h, and in multiple dose studies continued at 8-h intervals for 72-144 h.