Biophysical Aspects of Cyclodextrin Interaction with Paraoxon

摘要

Cyclodextrins are torus-shaped polymers of glucose that can bind organophosphorous compounds such as nerve agents and pesticides.We demonstrate here that cyclodextrin can bind up to two paraoxon molecules with a Kav of 6775M-1. Molecular modeling shows that the paraoxon appears to bind in polar opposite orientation and have an average binding energy of -89 Kcals/mol.