SIRT3 Is a Mitochondrial Tumor Suppressor and Genetic Loss Results in a Murine Model for ER/PR-Positive Mammary Tumors Connecting Metabolism and Carcinogenesis.

摘要

The mammalian Sirtuin genes are homologs of the yeast Saccharomyces cerevisiae Sir2 gene that is implicated in the regulation of longevity (Haigis et al., 2012). There are seven Sirtuin proteins, with SIRT1, SIRT6, and SIRT7 localized in the nucleus, SIRT2 localized in the cytoplasm and SIRT3, SIRT4, and SIRT5 localized in the mitochondria (Finkel et al., 2009). The mitochondrial deacetylase SIRT3 is thought to act on numerous substrates to regulate seevral processes including fat and amino-acid metabolism as well as electron transport (Huang et al., 2010).