Ovarian Mouse Models with Targeted Fallopian Tubal Carcinogenesis.

摘要

To test the idea that ovarian cancer arises from oviductal epithelium, spreads to the ovary, and presents as ovarian cancer, we generated a mouse model in which we can target genetic deletions to the oviductal epithelium. We are currently performing selective genetic deletion of ovarian cancer genes, such as TP53, Rb, and BRCA1 in oviductal epithelium in this mouse model. Interim analysis of the ongoing studies provided encouraging results. The mouse models we have generated using Ovgp1-CreERT2 are starting to generate ovarian and ductal tumors with a long latency of approximately 20 months. This long latency is similar to the natural history of human ovarian cancer as the majority of sporadic ovarian cancer is considered late onset. In addition, we also observed some tumor bearing mice have ascites and some dont reflecting the similar spectrum of disease presentation in human. Finally, we have provided these mouse models to three investigators so that they can use these models in their ongoing studies.