LP1846 Liquid Gun Propellant Dermal Toxicity Study in Male Miniature Hanford Swine.

摘要

LP1846 Liquid Gun Propellant is under development by the U.S. Army as a possible substitute for solid gun propellants. Available toxicity data on liquid gun propellant formulations and/or their major components, indicate toxicities in exposed rats, guinea pigs, rabbits and miniature swine. The major toxic effects of these monopropellants are attributed to the ingredient hydroxylammonium nitrate and result in erythrocyte crenation, Heinz body formation and methemoglobin production. This range-finding study was conducted to establish a dose response curve, based upon single topical applications of undiluted LP1846 at selected skin surface area exposures in male Hanford Miniature Swine. The data were necessary to select optimal skin surface areas to be exposed in follow-on definitive toxicity studies. RA 3; Heinz bodies; Methemoglobinemia; Liquid propellants; Hydroxylammonium nitrate; HAN; LP1846; Miniature swine; Nitrates.