Comparison of the Systemic and Microvascular Responses to Uncontrolled Hemorrhage in Anesthetized Rabbits.

摘要

We studied the systemic and microvascular responses to moderate, uncontrolled aortic or vena caval hemorrhage in skeletal muscle. Both systemic arterial pressure and systemic hematocrit fell following hemorrhage. Arterial pressure recovered moderately by 30 minute post-hemorrhage. The drop in hematocrit following hemorrhage was due to translocation of interstitial and intracellular water into the vascular compartment; ie., transcapillary refill. This change in hematocrit was similar following both types of hemorrhage. Transverse (pre-terminal) and terminal arterioles in the tenuissimus (skeletal) muscle of the rabbit constricted somewhat, however, the greatest constriction was in the terminal arterioles.