Molecular Recognition in the Solid State Controlled Assembly of Hydrogen-BondedMolecular Sheets

摘要

A novel hydrogen bonding motif for the control of solid state structures has beendeveloped. The motif is based on the hydrogen bonding complementarity of carboxylic acids with 2-aminopyridine derivatives. Linking two aminopyridine groups through a rigid aromatic spacer provides a receptor unit that can complex dicarboxylic acids. When there is a good correspondence between the length of the spacer and that of the carboxylic acid a discrete 1:1 complex is formed. When the dicarboxylic acid is longer than the receptor an alternating hydrogen bonded cocrystal occurs with the carboxylates on each diacid binding to different receptors. This motif dominates the cocrystal, forming even when the relative lengths of the diacid and the receptor change. Within the constraints of the alternating ribbon structure the spatial position of the two components can be varied in a well defined and predictable manner.... Molecular recognition, Hydrogen bonding, Controlled crystal Structures.