Immunogenicity of Salmonella typhi Ty21a Vaccine for Young Children

摘要

An attenuated Salmonella typhi Ty21a vaccine was administered to 18 infants andtoddlers greater but less than 24 months old) to determine its safety and immunogenicity. The vaccination (10' CFU per dose, three doses) was well tolerated. However, after the vaccination there was no evidence of a humoral or cellular immune response to S. typhi. The vaccine used was known to be immunogenic for older children and adults. The results support the view that the immunogenicity of Ty2la is age dependent.