Synthesis and Chemistry of a New, Functionalized Polycyclic Azoalkane. A NovelEntry into the Homopentaprismane Ring System

摘要

As part of a general program that is concerned with the synthesis and chemistryof novel, substituted pentacycloundecanes, we have recently undertaken the synthesis of some unusual cage amines via reductive amination of pentacyclo undecane-8,11-dione and sodium borohydride and sodium cyanoborohydride reduction of PCUD-8,11-dione monobenzylimine. Roughly spherical case amines of this type are of interest as analogues of 1-aminoadamantane, whose activity as an antiviral and anti-Parkinsonism agent is well established.