Interactions between Pyridostigmine and the Anti-emetics Ondansetron andGranisetron

摘要

The aim of this study is to assess the pharmacological, physiological,psychological and subjective effects, relevant to military performance, of the concurrent administration of the 5HT3-antagonist anti emetics ondansetron or granisetron to the nerve agent pretreatment pyridostigmine. The study follows a within-subject design to compare the actions of pyridostigmine alone with those of pyridostigmine and 5HT3-antagonist, and a between-subject design to assess the effects of starting the two drugs simultaneously rather than sequentially.