N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide (W7) Stimulation of K(+)Transport in a Human Salivary Epithelial Cell Line

摘要

Treatment of a human salivary epithelial cell line, HSG- PA, with the calmodulinantagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide increased RB (K+) influx and efflux in a manner similar to that resulting from muscarinic (carbachol; Cch) or calcium ionophore (A23187) stimulation. Unlike the Cch or A23187 responses, the W7 responses were not blocked by 0.1 mM atropine