Further Evaluation of Mutagen-Attenuated Rift Valley Fever Vaccine in Sheep

摘要

The outbreak of Rift Valley fever (RVF) in Egypt in 1977 was the first reportedoccurrence of Rift Valley fever virus (RVFV) outside sub-Saharan Africa. This epidemic emphasized the role of RVFV as a significant human pathogen and established the virus as a potential worldwide threat to human and livestock populations. Concern over further dissemination of the virus has prompted efforts to develop improved vaccines, as available formalin inactivated and live-attenuated vaccines have disadvantages or practical limitations to their widespread use. The 1987 RVF outbreak in western Africa re-emphasized the continuing threat of RVF to humans and animals and the need for a safe, effective vaccine suitable for large-scale immunizations.