Combination of Resveratrol and Zinc for Prostate Cancer Management.

摘要

The goal of this project is to determine if resveratrol can enhance the anti-proliferative response of Zinc (Zn) against prostate cancer (PCa) via increasing ZIP1 mediated Zn transport. Our proposed in vivo pre-clinical experiments in PTEN mouse model of PCa are currently under progress. We are currently breeding the prostate specific PTEN knockout mice and have also started experiments with another transgenic model (TRAMP) model, due to their ready availability. Further, in additional experiments we have found that that ZIP1 protein is markedly downregulated in human PCa tissue and cell lines compared to normal prostate tissue and normal RWPE-1 cells. In cell culture, resveratrol-Zn combination was found to result in a marked increase in ZIP1 mRNA and protein in PCa cells. In addition, resveratrol-Zn resulted in a superior anti-proliferative response in PCa cells, compared to either of the agent alone. Although, the data from the completed in vivo trial will be available after the completion of studies, our initial observations coupled with in vitro data suggests that our hypothesis may be valid and resveratrol- Zn combination may have superior anti-proliferative response against PCa.