Multiple Dose Pyridostigmine Administration: Cardiovascular Effects at Restduring Acute Heat and Altitude Exposure

摘要

Two separate studies of pyridostigmine bromide ingestion (PB, 30 mg, t.i.d.) wereconducted. In one study, five subjects were studied at rest in a hot environment (35 C) . In a second study, four subjects were studied in a warm environment (31 C) at sea level and at 10,000 feet. Esophageal (Tes) temperature, heart rate (HR), arterial blood pressure, forearm blood flow and forearm skin blood flow were measured. Red blood cell cholinesterase activity (RBC AchE) was used as an index of PB effectiveness. RBC AchE activity was inhibited -31 to -47%. In STUDY 1, resting Tes and heart rate were lower after 50 hours of pyridostigmine