Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulation as a PotentialBlood Substitute

摘要

During the last four months of our project entitled 'Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulation as a Potential Blood Substitute', efforts have been made in the following four areas: (1) the resynthesis of LR16; (2) physical characterization of LEH/LR16 formulations; (3) design and development of membrane-impermeable LR16 analogues; and (4) preparations for small animal testing of surrogate blood preparations. The work completed in each of these areas is outlined below.