Investigation of Crimean-Congo Hemorrhagic Fever and Hemorrhagic Fever with RenalSyndrome in Greece

摘要

During a 14 month period from April 1989 to June 1990, human serosurveys forCrimean-Congo Hemorrhagic fever (CCHF) and Hemorrhagic Fever with Renal Syndrome (HFRS) were conducted in several counties of Greece previously not surveyed. Blood samples were taken from patients suspected for Crimean-Congo Hemorrhagic Fever and Hemorrhagic Fever with Renal Syndrome and tested for specific CCHF and HFRS diagnosis. Small mammals were trapped from HFRS endemic areas for Hantaan virus isolation and ticks were also collected from CCHF endemic areas for CCHF virus isolation. Additionally, animal serosurvey was conducted in areas were human CCHF seropositives were found. Antibodies to Hantaan virus were detected in 31 out of 1679 individuals tested, and eight human HFRS cases were serologically diagnosed. The disease was severe and one of the patients died during the oliguric phase. Antibodies to CCHF virus were found in humans and animals and inapparent human CCHF infection was confirmed in a CCHF endemic area.