Human Erythrocyte as a Model for Investigating Muscarinic Agonists andAntagonists

摘要

Cholinergic muscarine receptors have been identified in the brain (Schiller,1979), neuromuscular junctions (Yamamura and Snyder, 1974) pylorus (Gaginella et al., 1980), cardiac aorta (Peterson and Schimerlik, 1982) and other tissues/organs by direct binding assays of radiolabeled cholinergic agonists or antagonists. It is well recognized that the cation channel, the anesthetic site, is coupled to cholinergic receptors (Aguilar et al., 1980). The cholinergic muscarinic agonists either stimulate cGMP production or inhibit cAMP production (Greengard, 1975). Recently numerous reports have alluded to the existence of four subtypes of muscarinic receptor that can be distinguished by their binding affinities and their amino acid sequences.