Zinc Status and Interleukin-1B Induced Mineral Metabolism Alterations in Rats.

摘要

Interleukin-1Beta (IL-1Beta) can alter Zn metabolism. Changes in Zn metabolism and IL-1Beta release occur in response to tissue injury and trauma. In this study, we examined whether Zn status modifies the effects of low dose IL- 1Beta administration on mineral metabolism. Rats were fed 50 ug Zn/g (AZn) or 5ug Zn/g (MZn) diets for 14d. On d 15, rats were infused via osmotic minipumps, with IL- 1Beta (2.3 ng/h) or saline (control, C) and euthanitized 1, 3 or 7d later. In the AZn rats, IL-1Beta infusion resulted in increased plasma Cu concentrations and ceruloplasmin (Cp) activity, and decreased Fe concentrations throughout the 7d period, that were most pronounced on dl and d3. A similar trend was observed in the MZn rats, but IL- 1Beta-induced increases in plasma Cu and Cp were less than in the A.Zn fed rats. In MZn and AZn IL- 1Beta infused rats, plasma Zn was decreased at d 1 and d3, respectively, compared with their respective controls. AZnIL-1Beta-infused rats were characterized by high liver Fe, Zn and metallothionein (MT) concentrations at dl; by 7d, only MT concentrations remained elevated. These data show that Zn status can influence the response to low dose IL-1Beta. This influence of Zn should be considered when IL- 1Beta is given to stimulate wound healing.... Continuous infusion, Cooper, Ceruloplasmin, Metallothionein, Zinc, IL-1Beta, Rats.