Effect of the Selective Kappa Opioid Agonist CI-977 on Glutamate-Induced LDHRelease from Cultured Rat Neurons

摘要

The present study demonstrated that the selective kappa opioid agonist CI-977 wasneuroprotective against glutamate toxicity in cortical-cell cultures. Dose-response analysis showed CI-977 to be equipotent-to the non-competitive NMDA antagonist MK-801. However, in contrast to MK-801 which was maximally protective against low (30 AM) and high (100 AM) concentrations of glutamate,