Surface-Differentiated Model Phospholipid Bilayers

摘要

Dipalmitoylphosphatidylcholine (DPPC) and dioleoylphosphatidylcholine (DOPC) weresynthesized in which the head groups were covalently functionalized with p-nitrophenyl benzoate (PNPB) moieties. Liposomes composed of 1 part functional lipid and 7 parts nonfunctional DPPC or DOPC were created at pH 6 and subjected to an exovesicular/endovesicular 12/6 pH gradient. Under these conditions, the