Study of the Effect of Hydrocarbon Structure on the Induction of Male RatNephropathy and Metabolite Structure

摘要

Male Fischer 344 rats were dosed with the saturated branched chain hydrocarbon 3-methylheptane. Pathological examination of the kidneys of the dosed animals compared to the kidneys of control rats dosed with water indicated that there was a noticeable difference in the ability of the hydrocarbon to induce the classic nephrotoxicity produced by 2,2,4-trimethylpentane and other branched chain hydrocarbons. Hyaline droplet formation was used as the principal indicator of kidney damage. There was little indication of any cast formation in the corticomedullary junction area of the kidney. Identification of the rat urinary metabolites of 3methylheptane yielded 3,5-diethyl-2,3-dihydrofuran, 3-ethyl-6-methyl-2,3-dihydropyran, 3-methyl-2-heptanol, 5-methyl-2-heptanol, 2-n-butyl-1,3-butanediol, 2-ethyl-1,3hexanediol, B-methyl-8-enantholactone, 3-methyl-3,4-heptanediol, 3-methyl-2,3heptanediol, 3-methyl-3,5-heptanediol, 2-ethyl-1,4-hexanediol, 8-methyl-8enantholactone, 5-methyl-2,5-heptanediol, 2-ethyl-1,5-hexanediol and 2-ethyl1-hexanoic acid.