Pathologic Changes Induced by Phospholipase A2 Isolated from the Venom of Collett's Snake, Pseudechis colletti: A Light and Electron Microscopic Study. (Reannouncement with New Availability Information).

摘要

Pseudechis colletti (Boulenger, 1902) is an uncommon species of Australian elapid snake which has a range limited to central Queensland. This species attains an average adult length of 1.25 m, with a recorded maximum length of 2 m. The venoms of P. colletti and a number of other Australian elapids have been shown to contain phospholipases A (PLA) which cause myoglobinuria in mice (MEBS and SAMEJIMA, 1980). It has been demonstrated that a large number of ophidian species secrete venoms which contain PLAs that are destructive to skeletal muscle (HARRIS et al., 1978; FOHLMAN and EAKER, 1977; MEBS and SAMEJIMA, 1986). Our observations were consistent with previous reports (BERNHEIMER et al., 1986, 1987), in which several fractions of this venom produced either clearing or turbidity after addition to a dilute solution of egg yolk. Phospholipases A cause clearing of dilute egg yolk suspensions while phospholipases B (PLB) cause turbidity (MARINETTI, 1965). We report here on the histopathological effects of a PLA, isolated from P. colletti venom.