Engineering Ultrastable Protein Filaments into 2D and 3D Templates for Advanced Nanomaterials: A New Dimension in Materials Design.

摘要

In this project we endeavoured to expand the realm of multidimensional protein assembly by generating new proteins that assemble into 2D and 3D shapes of controllable size and symmetry, for template-based construction of advanced biomaterials. We successfully created a standardized biomolecular construction kit comprised of a thermostable filamentous protein called gamma-prefoldin and complementary protein parts that can be assembled into diverse structures of controllable size and shape.