T Cell Clone Directed at the Circumsporozoite Protein which Protects Mice againstBoth Plasmodium yoelii and Plasmodium berghei. (Reannouncement with New Availability Information)

摘要

Clone B is a cytotoxic T cell clone induced by immunization with Plasmodiumyoelii sporozoites which recognizes an epitope on both the P. yoelii and Plasmodium berghei circumsporozoite proteins. It is CD8, uses the V beta 8/1 TCR, and is K(sup d) restricted. When adoptively transferred, it protects mice against infection by both species of malaria sporozoites, and this protection is dependent on IFN-gamma. Clone B cells are more broadly reactive and protective than previously described murine T cell clones against malaria. Clone B may be an important model for immune protection against the spectrum of variant parasites in nature.