首页> 美国政府科技报告 >Effect of Calcium Antagonists (Omega-Conotoxin GVIA, Verapamil, Gallopamil,Diltiazem) on Bronchial Smooth Muscle Contractions Induced by Soman
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Effect of Calcium Antagonists (Omega-Conotoxin GVIA, Verapamil, Gallopamil,Diltiazem) on Bronchial Smooth Muscle Contractions Induced by Soman

机译:钙拮抗剂(Omega-Conotoxin GVIa,维拉帕米,Gallopamil,Diltiazem)对soman诱导的支气管平滑肌收缩的影响

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摘要

The effect of the calcium antagonists omega-conotoxin GVIA, verapamil, gallopamiland diltiazem was investigated on in vitro bronchial smooth muscle contraction in the rat induced by the nerve agent soman. Soman inhibits the acetylcholinesterase activity irreversibly. The effect of the calcium channel antagonists on contractions induced by electrical field stimulation and carbachol was also investigated, in order to elucidate the mechanism by which calcium antagonists inhibit the soman induced contraction.

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