Isolation Suppresses Both Immune and Neuroendocrine Functioning and Decreases theLocomotor Activity of Normal and Immunosuppressed C3H/HeN Mice

摘要

This inter-disciplinary experiment examined the dramatic influence thatenvironmental variables can have on behavioral, neuroendocrine, and immune system parameters. In this study, we examined the effects of housing on locomotion, circulating lymphocytes, and catecholamines (i.e., Norepinephrine N and Epinephrine E) of 12-week-old female C3H/HeN mice. Ten week old female C3H/HeN mice (10/group) were either immunocompromised (following 0.5 Gy or 4.5 Gy 60Co gamma irradiation) or normal (sham-irradiated), and were housed in isolation (1/cage) or groups (10/cage) for 25 days following radiation exposure. All dependent variables were obtained on day 25 postirradiation. Isolation, Immune System, Neuroendocrine, Locomotor activity, Immunosuppression.