Physiologically Based Pharmacokinetic Model for the Oxime TMB-4: Simulation of Rodent and Human Data.

摘要

Multiple oximes have been synthesized and evaluated for use as countermeasures against chemical warfare nerve agents. The current U.S. military and civilian oxime countermeasure, 2- (hydroxyimino)(methyl) -1-methylpyridin-1-ium chloride (2-PAM), is under