Stretch-Activated Ion Channels in Tissue-Cultured Chick Heart. (Reannouncementwith New Availability Information)

摘要

Mechanical loading leads to a variety of cellular changes in the heart, includingalterations in the levels of intracellular Ca2+ and Na+ changes in the action potential including increases in automaticity increased synthesis of specific mRNAs polyribosomes and proteins and the secretion of peptides. The primary mechanical transducers are not generally known, but many of the effects can be explained by the presence of mechanically sensitive ion channels. Such channels are ubiquitous in the plant and animal kingdoms and across the phylogenetic spectrum. In cardiac muscle cells, the channels have been reported present in snail and in rat. Here we present data that show a variety of stretch-activated channels capable of generating both inward and outward currents in cultured chick cardiac myocytes.