Inhibition of c-kit Ligand/Steel Factor by Antibodies Reduces Survival ofLethally Irradiated Mice

摘要

Survival after irradiation with LD100/30 (radiation dose lethal to 100% of micein 30 days) is based on recovery of impaired hematopoietic function. Our previous studies using antibodies to interleukin-1 receptor (IL-lR), tumor necrosis factor (TNF), and IL-6 demonstrated that endogenous production of these three cytokines is required for untreated mice as well as mice protected with lipopolysaccharide (LPS), IL-1, or TNF to survive lethal irradiation. In this report we show that