Opioids: Epilepsy and Neuroprotection. (Reannouncement with New AvailabilityInformation)

摘要

This chapter presents an overview of the pharmacological effects of opioids onCNS excitability related to epilepsy and neuroprotection. Although the history of opioids and convulsive activity dates back to the middle nineteenth century, relatively little attention has been devoted to this area of opioid pharmacology. Since the initial observation that morphine caused convulsions in the frog, the general picture has been one of numerous reports describing a convulsive effect of extremely high doses of morphine (and its surrogates) in virtually all species. With the discovery that the endogenous Opioid peptides elicited nonconvulsive electrographic (EEG) seizures in rats, this profile of opioid-induced convulsive activity experienced a scientific renaissance.... Opioids, Epilepsy, Neuroprotection.