Comparison of Several Oximes on Reactivation of Soman-Inhibited Blood, Brain andTissue Cholinesterase Activity in Rats

摘要

The ability of three oximes, HI-6, MMB-4 and ICD-467, to reactivatecholinesterase (ChE) inhibited by the organophosphorus compound soman was compared in blood (plasma and erythrocytes), brain regions (including spinal cord) and peripheral tissues of rats. Animals were intoxicated with soman (100 ttg/kg. SC; equivalent to 0.9 x LDs0 dose) and treated 1 min later with one of these oximes (100 or 200 ttmo1/kg, IM). Toxic sign scores and total tissue ChE activities were determined 30 min later. Soman markedly inhibited ChE activity in