Chemoselective Reactions of Functionalized Piperidines.

摘要

The reduction-oxidation strategy for transformation of a cyano function into a carbomethoxy function was investigated as an alternative to the well-studied hydrolysis routes for viability with alpha-aminonitrile 2. Chemoselectivity problems were minimized when the reduction was effected with diisobutylaluminum hydride under inverse addition conditions.... Alpha-aminonitrile, Chemoselective reduction.