Acute and Subacute Toxicity of 7.5% Hypertonic Saline-6% Dextran-70 (HSD) inDogs. 2. Biochemical and Behavioral Responses

摘要

7.5 % Hypertonic saline-6 % Dextran-70 (HSD) is currently being evaluated in ourlaboratory as a resuscitation solution for the treatment of hypovolemia at a dose of 4 mI kg-1 body weight. A few reports of dextran toxicity, particularly of the kidney, have been cited in the literature, so the present study evaluated the acute and subacute toxicity of HSD administered i.v. to beagle dogs. In the acute toxicity studies animals were infused with a single dose of HSD, or its components of hypertonic saline (HS) or Dextran-70 (D-70), at the maximum tolerated dose (MTD: 20 mI kg-1). Controls received Ringers lactate (RL). In the HSD-infused dogs, transient but significant increases in serum alanine (ala) aminotransferase (AT), aspartate (asp) AT and alkaline phosphatase (AP) were observed for the first 72 h. In most cases this increase was also observed in the HS group. In the subacute studies, dogs were infused daily with the MTD of the above test solutions. Serum ala AT activity was 2-3-fold higher in the HSD than the RL, group for the first 3 days. Again, a similar effect was observed in the HS group. Slight, transient increases in asp AT and AP activity were also observed in the HSD group.... Hypertonic resuscitation, Dextran-70, Hypertonic saline, Aminotransferases, Creatinine, Lactate dehydrogenase, Dogs.