Immunotherapy of Tularemia: Characterization of a Monoclonal Antibody Reactivewith Francisella tularensis

摘要

An IgM monoclonal antibody (mAb) recognized surface antigens specific toFrancisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.... Antibodies, Francisella tularensis, Live vaccine strain, Lipopplysaccharide, Immunofluorescence assay, ELISA.